Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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6,106 – 6,120 of 178,527 results

6,106

Medchemexpress LLC Thieno[2,3-c]pyridine-2-propanoic acid, 4-(4-cyanophenyl)-α,α-dimethyl- | 2013582-27-7 | 100.0% | 336.41 | 5 MG

Puliginurad (YL-90148) is a potent urate transporter (URAT) inhibitor. It can be used for hyperuricemia and gout research.

Potent urate transporter (URAT) inhibitor
Used for hyperuricemia and gout research
Molecular formula: C₁₉H₁₆N₂O₂S
Targets URAT1
Pathway: Membrane Transporter/Ion Channel

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6,107

Apexbio Technology LLC (±)-Nutlin-3 548472-68-0 10mg

( )-Nutlin-3 (CAS 548472-68-0) is a small molecule antagonist of MDM2 a regulator that negatively modulates the tumor suppressor protein p53 By inhibiting the interaction between p53 and MDM2 (IC50 0 09 M) ( )-Nutlin-3 promotes p53 stabilization and activation leading to enhanced transcription of p53 target genes such as CDKN1A/p21 and GADD45 In cellular studies ( )-Nutlin-3 induces dose-dependent p53 accumulation and apoptosis including in B-cell chronic lymphocytic leukemia cells In murine xenograft models oral administration suppresses tumor growth and increases caspase-3 activity ( )-Nutlin-3 is widely used to investigate p53-dependent cell death and tumor biology in preclinical research

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6,108

Medchemexpress LLC 4-[[(2R)-1-(1-benzothiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-[(3-chlorophenyl)methyl]amino]but | 1391076-61-1 | MFCD28502087 | 98.1% | 485.00 | C25H25ClN2O4S | 5 MG

GLPG0974 is a small-molecule antagonist of the free fatty acid receptor 2 (FFA2/GPR43) provided as a research reagent. It shows potent activity in receptor assays (IC50 9 nM) and is supplied as a high-purity solid for in vitro pharmacology and biochemical studies. For research use only; not intended for human use.

Potent FFA2/GPR43 antagonism with IC50 9 nM.
High purity suitable for biochemical and cell-based assays.
Supplied as a solid for convenient handling and storage.
Characterized compound with CAS 1391076-61-1 and molecular weight 485.00.
Intended for laboratory research applications only.

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6,109

Medchemexpress LLC Masoprocol (meso-nordihydroguaiaretic acid) | 27686-84-6 | 99.3% | 302.36 g/mol | C18H22O4 | 5 MG

Masoprocol (meso-nordihydroguaiaretic acid) is a research-grade small molecule described as a lipoxygenase inhibitor with reported antihyperglycemic activity. Provided at milligram scale for in vitro and preclinical studies; not for human use.

High purity: 99.3%.
Molecular formula: C18H22O4.
Molecular weight: 302.36 g/mol.
Active as a lipoxygenase inhibitor and shows antihyperglycemic activity.
Supplied in milligram-scale quantities suitable for laboratory research.
Recommended storage: -20°C, protect from light; in solvent: -80°C up to 6 months, -20°C up to 1 month.
Intended for research use only, not for human consumption.

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6,110

Medchemexpress LLC Atuveciclib | 2923012-24-0 | 99.8% | 100 MG

Atuveciclib is a potent and highly selective oral PTEFb/CDK9 inhibitor that targets CDK9/CycT1 with an IC50 of 13 nM. It demonstrates potent antiproliferative activity against various cell lines, including HeLa (IC50=920 nM) and MOLM-13 (IC50=310 nM) in vitro. In vivo studies in the MOLM-13 xenograft model show high antitumor efficacy with dose-dependent results and good tolerability, with less than 10% mean body weight reduction. It also exhibits low blood clearance in rats.

Potent and highly selective oral PTEFb/CDK9 inhibitor
Inhibits CDK9/CycT1 with an IC50 of 13 nM
Demonstrates potent antiproliferative activity against various cell lines
Shows high antitumor efficacy in MOLM-13 xenograft model
Well-tolerated in vivo studies
Exhibits low blood clearance in rats

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6,111

Medchemexpress LLC Glun2b-Nmdar antagonist-1 | 3043727-74-5 | 99.4% | 475.38 | 100 MG

GluN2B-NMDAR antagonist-1 is an orally active GluN2B-NMDAR antagonist with neuroprotective activity, useful for research of ischemic injury. It improves cognitive ability and demonstrates good plasma stability.

Showed neuroprotection against NMDA-induced cell damage in SH-SY5Y cells.
Reduced NMDA-induced Ca2+ influx in SH-SY5Y cells.
Increased the downregulation of p-ERK1/2 expression induced by NMDA in SH-SY5Y cells.
Improved cognitive ability in an ICV-ET1-induced vascular dementia mouse model.
Decreased escape latency and swimming distance in the ICV-ET1-induced vascular dementia mouse model.

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6,112

Medchemexpress LLC N-(4-(2-tert-butylphenyl)sulfonylphenyl)-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide | 877877-35-5 | 99.5% | 5 MG

TW-37 is a small-molecule BH3 mimetic that inhibits Bcl-2 family proteins and induces apoptosis in target cells. It is characterized by biochemical Ki values against Mcl-1, Bcl-2, and Bcl-xL, and is supplied as a high-purity solid for research applications.

Potent inhibitor of Bcl-2 family proteins, including Mcl-1, Bcl-2, and Bcl-xL.
Reported Ki values: Mcl-1 260 nM, Bcl-2 290 nM, Bcl-xL 1110 nM.
High purity (99.5%) suitable for biochemical and cell-based assays.
Molecular formula C33H35NO6S and molecular weight 573.7 g/mol.
Available as a small solid package or as DMSO solutions for immediate use.

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6,113

Medchemexpress LLC Pyronaridine tetraphosphate | 76748-86-2 | 99.57% | 910.03 | 500 MG

Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. It is active against P. falciparum and Echinococcus granulosus infection. In vitro, it exhibits anti-P. falciparum activity with IC50 values in the nanomolar range (1.53-3.94 nM). In vivo, it has been shown to reduce parasitic burden in Echinococcus granulosus-infected mice and secondarily infected (cysts) mice, with higher exposure observed in the liver compared to plasma in male ICR mice.

Orally active.
Mannich base structure.
Demonstrates anti-malarial properties.
Effective against P. falciparum.
Effective against Echinococcus granulosus infection.
Reduces parasitic load in animal models.
Exhibits preferential distribution to the liver in animal studies.

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6,114

Medchemexpress LLC Baz1a-in-1 | 941521-45-5 | 99.9% | 340.36 | 5 MG

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein) with a KD value of 0.52 μM against the BAZ1A bromodomain. It exhibits good anti-viability activity against cancer cell lines that express high levels of BAZ1A, but shows weak or no activity against cancer cells with low BAZ1A expression.

Inhibits BAZ1A bromodomain
Shows anti-viability activity against cancer cell lines with high BAZ1A expression
Weak or no activity against cancer cells with low BAZ1A expression
Provided as a solid
High purity

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6,115

Medchemexpress LLC PT-65 | GSK3α/GSK3β PROTAC degrader | 2721998-87-2 | C51H63N13O12S | 1 ML

PT-65 is a PROTAC degrader targeting both GSK3α and GSK3β, with DC50 values of 28.3 nM and 34.2 nM, respectively. It works by inhibiting excessive tau phosphorylation, which is mediated by GSK3β, Aβ, and Okadaic acid. PT-65 is considered applicable for research related to Alzheimer's disease.

Dose-dependently reduces GSK3β-mediated tau hyperphosphorylation at serine 396, serine 404, and threonine 205 sites by inducing GSK3β degradation.
Protects SH-SY5Y cells from Aβ42-induced neurotoxicity by reducing GSK3 levels and subsequent tau hyperphosphorylation.
Ameliorates okadaic acid-induced learning and memory impairments in male Sprague-Dawley rats.
Reduces hippocampal GSK3α/β levels and tau hyperphosphorylation in vivo.

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6,116

Medchemexpress LLC (4R)-1-{[4,4-difluoro-1-(4-methoxyphenyl)cyclohexyl]carbonyl}-4-fluoro-N-1H-pyrazolo[4,3-b]pyridin-5-yl-d-prol... | 2259641-46-6 | 99.8% | 501.5 g·mol-1 | C25H26F3N5O3 | 10 MG

DS-9300 is a small-molecule, orally active, selective inhibitor of the EP300/CBP histone acetyltransferase (HAT) with a reported biochemical IC50 of 28 nM. Described in the Journal of Medicinal Chemistry and developed by Daiichi Sankyo, the compound has shown anticancer activity in preclinical prostate cancer models.

Potent EP300/CBP HAT inhibition (IC50 = 28 nM).
Orally active with demonstrated antitumor effects in preclinical prostate cancer models.
Selective activity for EP300/CBP over other HATs reported in the discovery study.
Provided as small-scale research quantities with analytical documentation available.
High reported purity (99.83%) and molecular formula C25H26F3N5O3.
Molecular weight approximately 501.5 g·mol-1.

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6,117

Medchemexpress LLC IRAK4-IN-20 | 1931994-80-7 | C22H25F3N4O3 | 100 MG

IRAK4-IN-20 (Compound BAY-1834845) is an orally active IRAK4 inhibitor with an IC50 of 3.55 nM. It can be used for acute respiratory distress syndrome (ARDS) research. It effectively prevents acute respiratory distress syndrome in mice and decreases inflammatory cytokines secretion effectively in LPS stimulated human peripheral blood mononuclear cells (PBMC).

Orally active IRAK4 inhibitor
IC50 of 3.55 nM
Used for acute respiratory distress syndrome (ARDS) research
Decreases inflammatory cytokines secretion in LPS stimulated human PBMC
Prevents acute respiratory distress syndrome in mice

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6,118

Medchemexpress LLC Ns2b/NS3-in-2 | 3010940-08-3 | 98.1% | 463.51 g/mol | C24H21N3O5S | 5 MG

NS2B/NS3-IN-2 is a research-grade covalent inhibitor of dengue virus NS2B/NS3 protease with potent biochemical activity and reported lack of cytotoxicity in assay systems. It is supplied as a high-purity powder intended for laboratory research use only.

Potent NS2B/NS3 protease inhibition (IC50 6.0 nM).
Binding affinity Ki of 0.66 μM.
High purity: 98.1%.
Molecular formula C24H21N3O5S; molecular weight 463.51 g/mol.
Soluble in DMSO at 100 mg/mL; in vivo formulation example 10% DMSO/90% corn oil.
Storage: powder -20°C (up to 3 years); in solution -80°C (up to 6 months).
For research use only; not for human or clinical use.

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6,119

Medchemexpress LLC 2 -O-Moe-5-Me-C Bz 5G | HY-W570890-5G

2 -O-Moe-5-Me-C Bz 5G

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6,120

Apexbio Technology LLC (+)-Igmesine hydrochloride 130152-35-1 10mg

( )-Igmesine hydrochloride (CAS 130152-35-1) is a selective sigma-1 ( 1) receptor ligand with an IC50 of 19 1 nM Sigma-1 receptor modulators are known to influence central neurotransmitter systems including noradrenergic glutamatergic and dopaminergic pathways In vitro studies indicate that treatment with ( )-Igmesine leads to a notable reduction in -adrenergic receptor density and tyrosine hydroxylase activity without affecting 1 5-HT1A or GABAB receptor levels The compound does not inhibit monoamine oxidase A or B activity In vivo it exhibits limited effects on norepinephrine uptake and does not alter serotonin or dopamine synthesis ( )-Igmesine also interferes with the NMDA receptor/NOS/cGMP pathway It is primarily utilized in research investigating sigma-1 receptor functions and potential antidepressant mechanisms Clinical studies have not yet been conducted

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Pyridines and derivatives

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Medchemexpress LLC Thieno[2,3-c]pyridine-2-propanoic acid, 4-(4-cyanophenyl)-α,α-dimethyl- | 2013582-27-7 | 100.0% | 336.41 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC (±)-Nutlin-3 548472-68-0 10mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Masoprocol (meso-nordihydroguaiaretic acid) | 27686-84-6 | 99.3% | 302.36 g/mol | C18H22O4 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Atuveciclib | 2923012-24-0 | 99.8% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Glun2b-Nmdar antagonist-1 | 3043727-74-5 | 99.4% | 475.38 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N-(4-(2-tert-butylphenyl)sulfonylphenyl)-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide | 877877-35-5 | 99.5% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pyronaridine tetraphosphate | 76748-86-2 | 99.57% | 910.03 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Baz1a-in-1 | 941521-45-5 | 99.9% | 340.36 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PT-65 | GSK3α/GSK3β PROTAC degrader | 2721998-87-2 | C51H63N13O12S | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC IRAK4-IN-20 | 1931994-80-7 | C22H25F3N4O3 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ns2b/NS3-in-2 | 3010940-08-3 | 98.1% | 463.51 g/mol | C24H21N3O5S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2 -O-Moe-5-Me-C Bz 5G | HY-W570890-5G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC (+)-Igmesine hydrochloride 130152-35-1 10mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More